TMRM Perchlorate

CAS No. 115532-50-8

TMRM Perchlorate ( T668 )

Catalog No. M22487 CAS No. 115532-50-8

TMRM Perchlorate is a cell-permeant cationic lipophilic red fluorescent dye (λex=530 nm, λem=592 nm). TMRM Perchlorate is a fluorescent probe (excitation, 530±21 nm; emission, 592±22 nm). In the presence of TMRM Perchlorate (2 μM) the coupled respiration with Complex I substrates or upon the addition of Complex II substrate is decreased by 27%.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 35 In Stock
10MG 58 In Stock
25MG 111 In Stock
50MG 205 In Stock
100MG 335 In Stock
200MG 465 In Stock
500MG 754 In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    TMRM Perchlorate
  • Note
    Research use only, not for human use.
  • Brief Description
    TMRM Perchlorate is a cell-permeant cationic lipophilic red fluorescent dye (λex=530 nm, λem=592 nm). TMRM Perchlorate is a fluorescent probe (excitation, 530±21 nm; emission, 592±22 nm). In the presence of TMRM Perchlorate (2 μM) the coupled respiration with Complex I substrates or upon the addition of Complex II substrate is decreased by 27%.
  • Description
    TMRM Perchlorate is a cell-permeant cationic lipophilic red fluorescent dye (λex=530 nm, λem=592 nm). TMRM Perchlorate is a fluorescent probe (excitation, 530±21 nm; emission, 592±22 nm). In the presence of TMRM Perchlorate (2 μM) the coupled respiration with Complex I substrates or upon the addition of Complex II substrate is decreased by 27%. The fluorescence signal in the presence of TMRM Perchlorate shows a slight decrease after the addition of glutamate, indicative of increased polarization of the mitochondrial inner membrane. Exposure of hippocampal cultures to high concentrations of TMRM Perchlorate (1 to 25 μM) stains mitochondria selectively and quickly, reaching a plateau after 5 to 10 min. Exposure of hippocampal cultures to low concentrations of TMRM Perchlorate (50 to 500 nM) for 1 to 3 hours results in selective staining of mitochondria in both neurons and the underlying glial cells. Low concentrations of TMRM Perchlorate (50 to 200 nM) do not induce apoptosis, whereas higher concentrations (0.5 and 2.5 μM) enhance apoptosis (KD?=?500 nM).
  • Synonyms
    T668
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    115532-50-8
  • Formula Weight
    500.93
  • Molecular Formula
    C25H25ClN2O7
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:41.67 mg/mL (83.19 mM; Need ultrasonic)
  • SMILES
    [O-]Cl(=O)(=O)=O.COC(=O)c1ccccc1-c1c2ccc(cc2[o+]c2cc(ccc12)N(C)C)N(C)C
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Chowdhury SR, et al. Simultaneous evaluation of substrate-dependent oxygen consumption rates and mitochondrial membrane potential by TMRM and safranin in cortical mitochondria. Biosci Rep. 2015 Dec 8;36(1):e00286.
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